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Since 90% of the bodys serotonin originates in the gut, these peripheral effects could influence central serotonergic tone through vagal signaling

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Therefore, targeting GS may represent a viable strategy for combating cancer metastasis and improving survival rates in patients with malignant tumors

PMID: 46

60,61 Overview of ferroptosis Ferroptosis is a cellular response to oxidative stress that depends on excess iron, phospholipids (PLs) with polyunsaturated fatty acid chains (PUFAs), and ROS